[Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate].

[Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate].

Eksperimental'naia i klinicheskaia farmakologiia (2013-05-02)

M A Iudin, S V Chepur, V N Bykov, A F Kurpiakova, S N Subbotina, A S Nikiforov, I M Ivanov

摘要

The effect of memantine administration has been studied on the model of mice poisoning with an anticholinesterase compound. It is established that the memantine action is due to its influence on the cholinesterase activity in the brain, blood plasma, and erythrocytes in addition to its NMDA-blocking action. Memantine promotes oxime-induced erythrocyte enzyme reactivation on the model of mice poisoning with anticholinesterase compound (0.8 LD50).

材料

货号

品牌

产品描述

C3389

Sigma-Aldrich

乙酰胆碱酯酶来源于电鳗, Type VI-S, lyophilized powder, 200-1,000 units/mg protein

M3262

Sigma-Aldrich

N-甲基- D -天冬氨酸, ≥98% (TLC), solid

C2888

Sigma-Aldrich

乙酰胆碱酯酶来源于电鳗, Type V-S, lyophilized powder, ≥1,000 units/mg protein

C1682

Sigma-Aldrich

乙酰胆碱酯酶人, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (Lowry)

C0663

Sigma-Aldrich

乙酰胆碱酯酶来源于人类红细胞, buffered aqueous solution, ≥500 units/mg protein (BCA)