- Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.
Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.
Proceedings of the National Academy of Sciences of the United States of America (1978-09-01)
C H Li, D Chung, D Yamashiro, C Y Lee
PMID212744
摘要
A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity of the peptide is estimated to be 30% of the potency of ACTH. It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.
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