- Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity.
Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity.
Bioorganic & medicinal chemistry (2008-03-18)
Robert Musiol, Dominik Tabak, Halina Niedbala, Barbara Podeszwa, Josef Jampilek, Katarina Kralova, Jiri Dohnal, Jacek Finster, Agnieszka Mencel, Jaroslaw Polanski
PMID18342517
摘要
Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard (DCMU). The structure-activity relationships are discussed.