- A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells.
A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells.
Chemical communications (Cambridge, England) (2018-03-27)
Changyu Zhang, Qichang Nie, Ismail Ismail, Zhen Xi, Long Yi
PMID29577151
摘要
A new fluorescence probe was developed for HClO detection under physiological conditions, which displayed fast response (t1/2 < 30 s) and large off-on fluorescence increase (>1000-fold) toward HClO with high sensitivity and selectivity. The probe was successfully applied for the detection of both exogenous and endogenous HClO in living cells. Using the probe-based tool, we could observe the H2S-induced HClO biogenesis in living cells for the first time.