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  • Cortical microvascular changes in chronological aging, cortical insults and chronic alcohol intoxication in rats. Effects of antihypoxic drug on these phenomena.

Cortical microvascular changes in chronological aging, cortical insults and chronic alcohol intoxication in rats. Effects of antihypoxic drug on these phenomena.

Alcohol (Fayetteville, N.Y.) (1989-11-01)
P De Witte, M Gewiss, C Heidbreder
摘要

Chronic alcohol pulmonary exposure in rats produced a cortical hypervascularization from one to four weeks after the onset of the alcoholization procedure. This alcohol-induced cortical hypervascularization, resembling closely the enhanced cortical vascular network observed in chronologically aged rats as well as around a lesion-induced cavity performed on the cortex, was significantly reduced by a concomitant treatment with Sabeluzole, a chemically benzothiazol derivative with antihypoxic and antiischaemic properties. The blood alcohol level of rats treated with the antihypoxic agent remained stable and constant at a mean level of 1 g/l during a whole 2-week-alcoholization duration in contrast to that of untreated rats which was directly related to the increased alcohol concentration of the atmosphere insufflated in the alcoholization chamber. Finally, a free-choice paradigm achieved after the chronic intoxication also revealed that Sabeluzole-treated rats chose to drink less alcohol as compared to untreated rats suggesting Sabeluzole well modulated the alcohol-induced behavioral preference.

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Sigma-Aldrich
Sabeluzole, ≥98% (HPLC)