- Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe.
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe.
Chemical communications (Cambridge, England) (2011-09-17)
Haibin Shi, Xiamin Cheng, Siu Kwan Sze, Shao Q Yao
PMID21922114
摘要
A clickable, affinity-based probe (AfBP), which was modified from staurosporine (a natural product kinase inhibitor), has been synthesized and used in situ for activity-based proteome profiling of potential cellular targets of staurosporine in HepG2 cancer cells.
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