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生物源
human
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
~22.3 kDa
包裝
pkg of 20 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell based assay: suitable
雜質
endotoxin, tested
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... CSH1(1442)
一般說明
Human placental lactogen (HPL), also called human chorionic somatomammotropin 1, is a polypeptide placental hormone. Its structure and function is similar to that of growth hormone. The gene encoding this protein is localized on human chromosome 17. Recombinant human placental lactogen is a 22.3kDa protein.
生化／生理作用
Human placental lactogen (HPL) modifies the metabolic state of the mother during pregnancy to facilitate the energy supply, glucose supply and growth of the fetus. Studies show that targeted expression of this protein in transgenic mice lead to an increase in proliferation of β-cells.
外觀
Sterile filtered and lyophilized with no additives.
重構
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases.
Zinuo Chen et al.
Cell & bioscience, 11(1), 45-45 (2021-03-01)
In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2
A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.
Freathy RM
Journal of Negative Results in Biomedicine, 5, 18-18 (2006)
Meltem Muftuoglu et al.
Nucleic acids research, 34(1), 295-304 (2006-01-18)
Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, severe neurological abnormalities and prageroid symptoms. The CS complementation group B (CSB) protein is involved in UV-induced transcription coupled repair (TCR), base excision repair and general
Placental lactogen is expressed but is not translated into protein in breast cancer.
Tuttle TR
PLoS ONE, 9(1), e87325-e87325 (2014)
Jaeyong Cho et al.
Biochemical and biophysical research communications, 579, 110-115 (2021-10-02)
The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones
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