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Merck
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文件

SML2548

Sigma-Aldrich

MS094

≥98% (HPLC)

别名:

2-[Methyl[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]amino]-ethanol

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About This Item

经验公式（希尔记法）:
C17H24N2O2
CAS号:
1831110-55-4
分子量:
288.38
分類程式碼代碼:
51111800
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CN(CCO)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2

生化／生理作用

MS094 i an inactive control probe for PRMT inhibitor MS023. MS023 is a potent and selective chemical probe for Type I protein arginine methyltransferases (PRMTs) 1,3,4,6,and 8, which are responsible for asymmetric dimethylation of arginine residues. MS023 is active in cells.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity.
Dane, et al.
Frontiers in Cellular Neuroscience, 17, 1134090-1134090 (2023)
Mohammad S Eram et al.
ACS chemical biology, 11(3), 772-781 (2015-11-26)
Protein arginine methyltransferases (PRMTs) play a crucial role in a variety of biological processes. Overexpression of PRMTs has been implicated in various human diseases including cancer. Consequently, selective small-molecule inhibitors of PRMTs have been pursued by both academia and the

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