SMB00375
Nadifloxacin
≥98% (HPLC)
别名:
Nadifloxacin, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, Acuatim, Jinofloxacin, OPC-7251, 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
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所有图片(2)
About This Item
推荐产品
生物源
synthetic (Organic)
化驗
≥98% (HPLC)
形狀
powder
顏色
white to yellow
抗生素活性譜
Gram-negative bacteria
Gram-positive bacteria
作用方式
DNA synthesis | interferes
enzyme | interferes
儲存溫度
−20°C
InChI
1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
InChI 密鑰
JYJTVFIEFKZWCJ-UHFFFAOYSA-N
一般說明
Chemical structure: fluoroquinolone
Nadifloxacin is antimicrobial in nature, and is a fluorinated quinolone. It is highly potent against Gram-negative and Gram-positive bacteria, especially Propionibacteruim acnes.
生化／生理作用
Nadifloxacin is used as a topical antibacterial, which is bactericidal due to its capability of preventing the negative supercoiling of bacterial DNA. DNA supercoiling, replication, transcription are catalyzed by DNA gyrase. In Japan, it is used to treat skin infection and acne. Studies show, that nadifloxacin is capable of successfully treating green nail syndrome (GNS) caused by Pseudomonas aeruginosa.
儲存和穩定性
Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510) Non Combustible liquids.
其他說明
Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510): Non Combustible Solids
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Varsha Narayanan et al.
Dermatology and therapy, 4(2), 233-248 (2014-09-13)
Skin and soft tissue infections involve microbial invasion of the skin and underlying soft tissues and are estimated to affect 7-10% of hospitalized patients worldwide. Nadifloxacin, a topical fluoroquinolone, has been shown to be effective against aerobic Gram-negative, Gram-positive (including
Simon Müller et al.
Case reports in dermatology, 6(2), 180-184 (2014-09-10)
Green nail syndrome (GNS) caused by Pseudomonas aeruginosa is the most common bacterial nail infection. The treatment of GNS is challenging in many cases and recommendations based on clinical trials are lacking. We report two cases with GNS successfully treated
Ujwala Shinde et al.
Indian journal of pharmaceutical sciences, 74(3), 237-247 (2013-02-27)
Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the
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