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MAK218

Sigma-Aldrich

Tace 抑制剂筛选检测试剂盒

Sufficient for 100 Fluorometric tests

别名:

ADAM17抑制剂筛选试剂盒, ADAM金属肽酶结构域17, 肿瘤坏死因子α转换酶抑制剂筛选试剂盒

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About This Item

EC號碼:
200-664-3
分類程式碼代碼:
12352200
NACRES:
NA.84

檢測方法

fluorometric

儲存溫度

−20°C

基因資訊

human ... ADAM17(6868)
mouse ... ADAM17(11491)
rat ... ADAM17(57027)

一般說明

Tumor necrosis factor-a converting enzyme (TACE; ADAM17) is a member of the ADAM (A Disintegrin And Metalloprotease) protein family implicated in cell-cell and cell-matrix interactions. TACE activates Notch signaling in the epidermal cells and has a critical function in the maintenance of barrier immunity. It is also involved in neurogenesis and muscle development.

應用

Tace Inhibitor Screening Assay Kit has been used in TACE (TNFa converting enzyme) activity assays.

特點和優勢

Compatible with high-throughput handling systems.

適合性

适于筛选TACE抑制剂。

原則

The TACE Inhibitor Screening Assay Kit is a rapid, simple and sensitive assay that is suitable for high throughput screening of TACE inhibitors. TACE hydrolyzes a FRET-tagged substrate to release a fluorescent product (λex = 318/ λem = 449 nm), proportional to the enzymatic activity present.

仅试剂盒组分

产品编号
说明
  • TACE Assay Buffer
  • TACE Substrate
  • TACE Enzyme
  • Inhibitor Control, 0.1 mM GM6001

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H334

防範說明

P261 - P284 - P501

危險分類

Resp. Sens. 1

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 3

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Joseph Dosch et al.
Oncotarget, 8(39), 65090-65099 (2017-10-17)
ADAM17 (a disintegrin and metalloproteinase 17)/TACE (TNFα converting enzyme) has emerged as a potential therapeutic target in colorectal cancer (CRC) and other cancers, due in part to its role in regulating various tumor cell surface proteins and growth factors and

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