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Merck
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H3541

Sigma-Aldrich

HIPK3 (163-562), active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

DYRK6, FIST3, PKY, YAK1

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

重組細胞

expressed in baculovirus infected Sf9 cells

品質等級

200

產品線

PRECISIO® Kinase

化驗

≥70% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

比活性

41-56 nmol/min·mg

分子量

~49 kDa

UniProt登錄號

Q9H422

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... HIPK3(10114)

一般說明

HIPK3 (homeodomain-interacting protein kinase 3) is strongly expressed in the heart and muscle tissues. It is up-regulated in multidrug-resistant cells.

生化／生理作用

HIPK3 (homeodomain-interacting protein kinase 3) is a nuclear serine/threonine protein kinase and mainly controls death receptor signaling. HIPK3 is involved in the transcriptional corepression, cell differentiation, growth suppression and apoptosis. It is up-regulated in prostate cancer cells, resulting in increased resistance to Fas receptor-mediated apoptosis by disturbing association between FADD (fas-associated death domain) and caspase 8.

外觀

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Hsin-Chieh Lan et al.
Molecular and cellular biology, 27(6), 2027-2036 (2007-01-11)
Steroids are synthesized in adrenal glands and gonads under the control of pituitary peptides. These peptides bind to cell surface receptors to activate the cyclic AMP (cAMP) signaling pathway leading to an increase of steroidogenic gene expression. Exactly how cAMP
D A Begley et al.
Gene, 200(1-2), 35-43 (1997-12-31)
We have previously shown that several protein kinases are present in higher activity levels in multidrug resistant cell lines, such as KB-V1. We have now isolated a gene that codes for a putative protein kinase, PKY, of over 130 kDa
James F Curtin et al.
The Journal of biological chemistry, 279(17), 17090-17100 (2004-02-10)
Elevated endogenous JNK activity and resistance to Fas receptor-mediated apoptosis have recently been implicated in progression of prostate cancer and can promote resistance to apoptosis in response to chemotherapeutic drugs. In addition, JNK has been demonstrated to promote transformation of

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