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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~40 kDa
物種活性
mouse
技術
western blot: 1:500-1:1,000 using mouse brain
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
mouse ... F8A1(14070)
一般說明
Three sequence-identical paralogs of the factor VIII intronic transcript A (F8A) gene codes for huntingtin-associated protein 40 (HAP40) in humans. In amniotes, HAP40 is coded by a single-exon gene (SEG). The F8A or coagulation factor VIII-associated 1 (F8A1) gene is located on human chromosome Xq28.
免疫原
peptide corresponding to the mouse HAP40 protein (amino acids 314-325).
應用
Co-immunoprecipitates Huntingtin protein.
生化／生理作用
Huntingtin-associated protein 40 (HAP40) acts as an effector of Ras-related protein 5 (Rab5) It interacts with huntingtin (HTT). HAP40 may participate in the abnormal nuclear localization of mutant huntingtin identified in Huntington′s disease degenerating neurons.
標靶描述
HAP40 is a 40 kDa Huntingtin-associated protein. It islikely to contribute to the function of normal huntintinand is a candidate for involvement in the aberrantnuclear localization of mutant huntingtin found indegenerating neurons in Huntington′s
外觀
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin.
Seefelder, et al.
BMC Evolutionary Biology, 20, 162-162 (2021)
M F Peters et al.
The Journal of biological chemistry, 276(5), 3188-3194 (2000-10-18)
Huntington's disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the huntingtin protein. Currently, the function of normal huntingtin and the mechanism by which expanded huntingtin causes selective neurotoxicity remain unknown. Clues may come
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