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Merck
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文件

B7775

Sigma-Aldrich

[Hyp3]-Bradykinin

≥97% (HPLC), suitable for cell culture

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About This Item

经验公式（希尔记法）:
C50H73N15O12
CAS号:
37642-65-2
分子量:
1076.21
MDL號碼:
MFCD00076259
分類程式碼代碼:
12352200
PubChem物質ID:
329773302

product name

[Hyp3]-Bradykinin, ≥97% (HPLC)

化驗

≥97% (HPLC)

形狀

powder

技術

cell culture | mammalian: suitable

顏色

white

UniProt登錄號

P06767

儲存溫度

−20°C

SMILES 字串

N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C50H73N15O12/c51-32(15-7-19-56-49(52)53)45(73)64-22-10-18-38(64)47(75)65-27-31(67)25-39(65)43(71)58-26-40(68)59-34(23-29-11-3-1-4-12-29)41(69)62-36(28-66)46(74)63-21-9-17-37(63)44(72)61-35(24-30-13-5-2-6-14-30)42(70)60-33(48(76)77)16-8-20-57-50(54)55/h1-6,11-14,31-39,66-67H,7-10,15-28,51H2,(H,58,71)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,76,77)(H4,52,53,56)(H4,54,55,57)/t31-,32+,33+,34+,35+,36+,37+,38+,39+/m1/s1

InChI 密鑰

JXRLHZCEMXTCBN-DIBGMJQNSA-N

基因資訊

rat ... Tac1(24806)

Amino Acid Sequence

Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg

生化／生理作用

[Hyp3]-Bradykinin is a bradykinin receptor agonist used to differentiate bradykinin receptors in various cells, tissues and species.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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M Sasaguri et al.
Biochemical and biophysical research communications, 157(1), 210-217 (1988-11-30)
Aside from bradykinin (BK), a novel kinin, [Hydroxyproline3]-bradykinin ( [Hyp3]-BK), was isolated from the reaction mixture of human plasma and plasma protein Cohn's fraction IV-4 with trypsin. The liberated kinins were isolated based on procedures which we previously described for
D Regoli et al.
Life sciences, 55(10), 735-749 (1994-01-01)
Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characterization was made in the rabbit jugular vein and the guinea pig ileum, two widely
K Enjyoji et al.
FEBS letters, 238(1), 1-4 (1988-09-26)
The contents of hydroxyprolyl3-bradykinin in high molecular mass (HMM) kininogens from human and animal plasmas were examined by reversed-phase HPLC following their proteolytic scission by bovine plasma kallikrein. The relative contents of hydroxyprolyl3-bradykinin in kinins from HMM kininogens from pooled
M Hecker et al.
British journal of pharmacology, 111(1), 238-244 (1994-01-01)
1. To examine the possibility that angiotensin-converting enzyme (ACE) inhibitors modulate the action of bradykinin at the receptor level, their effect on the dilator response to bradykinin was studied in the isolated saline-perfused heart of the rabbit. 2. Continuous infusion
H Kato et al.
Agents and actions. Supplements, 38 ( Pt 1), 217-224 (1992-01-01)
Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of
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