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product name
顺铂, crystalline
形狀
crystalline
顏色
yellow
mp
270 °C (lit.)
抗生素活性譜
neoplastics
作用方式
DNA synthesis | interferes
起源
Corden
SMILES 字串
N.N.Cl[Pt]Cl
InChI
1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI 密鑰
LXZZYRPGZAFOLE-UHFFFAOYSA-L
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應用
顺-二氨基铂(II)二氯化物已用于：
- 耳蜗外植体细胞的活力测量
- 抑制卵巢癌细胞系中的细胞增殖和化学敏感性
- 口服鳞状细胞癌中MTT [3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑溴化物]细胞活力检测
生化／生理作用
有效的化学免疫治疗药物; 通过激活巨噬细胞和免疫系统的其他细胞来刺激免疫反应。顺铂处理的巨噬细胞在体外显示出增强的抗原呈递功能。治疗增加了巨噬细胞中NF-κB的含量和易位。顺铂的作用受激酶、磷酸酶和Ca2+/钙调蛋白的调节。与DNA二核苷酸d（pGpG）形成细胞毒性加合物，诱导链内交联。
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
特點和優勢
该化合物是细胞凋亡研究的特色产品。点击此处以了解更多的细胞凋亡特色产品。可访问sigma.com/discover-bsm了解更多关于用于其他研究领域生物活性小分子。
儲存和穩定性
本品室温保存。密封保存于通风良好处。干燥。详见安全数据说明书(Safety Data Sheet)。
訊號詞
Danger
危險分類
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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