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Merck

D6821

Sigma-Aldrich

盐酸多奈哌齐

≥98% (HPLC), powder, acetylcholinesterase inhibitor

别名:

1 H -茚-1-酮,2,3-二氢-5,6-二甲氧基-2-\ [\ [1-(苯甲基)-4-哌啶基] 甲基]-, 盐酸盐, E2020

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About This Item

经验公式(希尔记法):
C24H29NO3 · HCl
分子量:
415.95
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

盐酸多奈哌齐, ≥98% (HPLC)

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to off-white

溶解度

DMSO: ≥20 mg/mL
H2O: ≥20 mg/mL

儲存溫度

room temp

SMILES 字串

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl

InChI

1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2

InChI 密鑰

HLJIZAKUNCTCQX-UHFFFAOYSA-N

基因資訊

human ... ACHE(43)

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應用

用盐酸多奈哌齐进行量效实验,研究其改善尼古丁戒断所致小鼠环境条件反应缺陷的作用。还将其腹腔注射到大鼠体内,研究其改善社会行为缺陷、重复行为和多动的能力。

生化/生理作用

盐酸多奈哌齐一水合物是一种中枢作用的可逆性乙酰胆碱酯酶抑制剂。
盐酸多奈哌齐是一种含有有机化合物和非竞争性抑制剂的哌啶类药物。对治疗阿尔茨海默病(其中痴呆为突出症状)有效。已证实多奈哌齐可诱导认知能力和全身功能。其半衰期为 70 小时。

特點和優勢

该化合物收录于受体分类和信号转导手册的乙酰胆碱合成和代谢页面。想要浏览手册的其他页面, 请单击此处

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral - Eye Irrit. 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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