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Merck
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477R-1

Sigma-Aldrich

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

别名:

Melanoma-associated antigen C2

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP405, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (477R-14)
vial of 0.1 mL concentrate Research Use Only (477R-14-RUO)
vial of 0.5 mL concentrate (477R-15)
vial of 1.0 mL concentrate (477R-16)
vial of 1.0 mL concentrate Research Use Only (477R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (477R-17)
vial of 7.0 mL pre-dilute ready-to-use (477R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)

製造商／商標名

Cell Marque™

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

同型

IgG

控制

seminoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

一般說明

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.4 In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.5-7

品質

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

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其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Yao-Tseng Chen et al.
Human reproduction (Oxford, England), 26(12), 3232-3243 (2011-10-22)
Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined. The expression of 10 CT-X antigens (MAGEA, NY-ESO-1
Peter K Bode et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(6), 829-835 (2011-07-23)
Melanoma-associated gene C2 (MAGEC2) is a recently identified cancer testis antigen expressed in normal testicular and placental tissue. It has been detected in some human carcinomas, but its expression in primary testicular germ cell tumors is unknown. Immunohistochemistry was used
Annikka Weissferdt et al.
Human pathology, 46(3), 376-383 (2015-01-13)
Primary mediastinal seminomas are unusual tumors that can present in a pure form or as part of a mixed germ cell tumor. Contrary to testicular seminomas, little is known about the expression of novel immunohistochemical markers in mediastinal seminomas. This
Ran Zhuang et al.
Cancer immunity, 6, 7-7 (2006-04-06)
CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal adult testis. As with many other CT antigens, our knowledge is based mainly on mRNA expression data. In
A O Güre et al.
International journal of cancer, 85(5), 726-732 (2000-03-04)
Assays relying on humoral or T-cell-based recognition of tumor antigens to identify potential targets for immunotherapy have led to the discovery of a significant number of immunogenic gene products, including cancer-testis (CT) antigens predominantly expressed in cancer cells and male
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