412510
IRE1抑制剂I，STF-083010
The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
IRE1抑制剂I，STF-083010, N-[（2-羟基萘-1-基）亚甲基]噻吩-2-磺酰胺，N-[（2-羟基-1-萘基）亚甲基]-2-噻吩磺酰胺，ER-核信号1抑制剂I，ERN1抑制剂I，肌醇调节蛋白1抑制剂I，STF083010
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About This Item
推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
powder
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
yellow
溶解度
DMSO: 100 mg/mL, clear, yellow
運輸包裝
ambient
儲存溫度
2-8°C
一般說明
一种细胞可渗透的水杨基化合物，可直接靶向Ireα1并破坏Ire1-XBP1（X-box结合蛋白），从而在RPMI8226多发性骨髓瘤（MM）细胞中未折叠蛋白反应（UPR）途径。选择性抑制Ire1的ER应激引发的核酸内切酶活性，并在转基因XBP1-luc小鼠（硼替佐米1mg/kg和60 mg/kg STF-083010，i.p.）中以60 µM和XBP1活性阻断MM细胞中XPB1 mRNA的剪接。与B、T和NK细胞相比，对CD138+细胞表现出优先的细胞毒性和抗肿瘤特性。
包裝
用惰性气体包装
警告
毒性：监管审查（Z）
重構
溶液中不稳定；仅在使用前进行复溶。
其他說明
Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010.Blood117, )1311.
Papandreou, I., et al. 2010.Blood117, )1311.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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eLife, 11 (2022-05-11)
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous
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Nature communications, 14(1), 4119-4119 (2023-07-12)
The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce toxicity in retinal cells remain poorly understood. Here, we integrate
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Frontiers in neuroscience, 16, 906651-906651 (2022-07-06)
Astrocytes are one of the most numerous glial cells in the central nervous system (CNS) and provide essential support to neurons to ensure CNS health and function. During a neuropathological challenge, such as during human immunodeficiency virus (HIV)-1 infection or
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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