217460

Cardiogenol C

A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC₅₀ = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM.

• 别名: Cardiogenol C, 2-(4-Methoxyanilino)-4-(1-hydroxyethylamino)pyrimidine
• 经验公式（希尔记法）: C₁₃H₁₆N₄O₂
• CAS号: 671225-39-1
• 分子量: 260.29
• MDL號碼: MFCD06798334
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H
• InChI 密鑰: QQAHYSZVJLHCNA-UHFFFAOYSA-N

说明

一般說明

A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC₅₀ = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM. The induction of cardiomyogenesis by Cardiogenol C is much more efficient than that achieved by EBs (embryoid bodies) formation and DMSO treatment.

A cell-permeable pyrimidine compound that potently induces the differentiation of embryonic stem cells (ESCs) into cardiomyocytes (EC₅₀ = 100 nM). Does not exhibit cytotoxic effects even at concentrations as high as 25 µM. The induction of cardiomyogenesis by Cardiogenol C is reported to be more efficient than that achieved by embryoid bodies (EBs) and DMSO treatment.

生化／生理作用

Cell permeable: yes

EC50 = 100 nM inducing the differentiation of ESCs (embryonic stem cells) into cardiomyocytes

Primary Target
Differentiation of ESCs (embryonic stem cells) into cardiomyocytes

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Wu, X., et al. 2004. J. Am. Chem. Soc.126, 1590.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable