14-840-M
AMPK (α1, β1, γ1) 蛋白，活性，10 µg
Active, recombinant, human AMPK (α1, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα1, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.
别名:
AMPK kinase
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所有图片(1)
About This Item
分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.32
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一般說明
Research area: Cell Signaling
Product Source: Expressed in E. coli cells and activated in vivo.
Protein Target: AMPK (α1, β1, γ1)
Target Sub-Family: CAMK
Recombinant, human AMPK (α1, β1, γ1) holoenzyme, comprised of full- length N-terminal 6His-tagged AMPKα1, full length untagged AMPKβ1 and full length untagged AMPKγ1. The AMPK α catalytic subunit in mammals is encoded by α1 and α2, two β genes β1 and β2 and three γ subunit genes γ1, γ2, and γ3.
Product Source: Expressed in E. coli cells and activated in vivo.
Protein Target: AMPK (α1, β1, γ1)
Target Sub-Family: CAMK
Recombinant, human AMPK (α1, β1, γ1) holoenzyme, comprised of full- length N-terminal 6His-tagged AMPKα1, full length untagged AMPKβ1 and full length untagged AMPKγ1. The AMPK α catalytic subunit in mammals is encoded by α1 and α2, two β genes β1 and β2 and three γ subunit genes γ1, γ2, and γ3.
應用
活性重组人AMPK（α1、β1、γ1）全酶，由全长N末端6His标记的AMPKα1，全长未标记的AMPKβ1 & 全长未标记的AMPKγ1组成。用于激酶测定。
研究子类别
糖尿病
肥胖症
代谢紊乱
糖尿病
肥胖症
代谢紊乱
研究类别
代谢
凋亡 & 癌症
代谢
凋亡 & 癌症
生化／生理作用
Under conditions of nutrient scarcity, AMPK functions as a metabolic checkpoint and inhibits cellular growth. Upon activation, AMPK promotes glucose uptake and fatty acid oxidation thereby reducing energy-consuming processes like protein and lipid synthesis. Furthermore, AMPK regulates autophagy and mitophagy. It also facilitates catabolic pathways to generate more ATP as a response to decreased ATP production.
包裝
也提供250µg规格（目录号14-840M）-请查询价格和供货情况。
品質
通过底物肽的磷酸化进行常规评估
外觀
钴琼脂糖
儲存和穩定性
在-70°C下可保存6个月
其他說明
比活相关数据，请参阅检验报告以获取该酶的单独批次。
法律資訊
GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
AMPK: guardian of metabolism and mitochondrial homeostasis
Herzig S and Shaw RJ
Molecular Cell Biology, 19, 121?135-121?135 (2018)
AMPK and the biochemistry of exercise: Implications for human health and disease
Richter EA and Ruderman NB
The Biochemical Journal, 418(2), 261?275-261?275 (2009)
The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism
Mihaylova MM and Shaw RJ
Nature Cell Biology, 13(9), 1016?1023-1016?1023 (2011)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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