生物来源
rabbit
质量水平
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
rat, mouse
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
基因信息
human ... NOTCH1(4851)
一般描述
The Notch protein family is a group of highly conserved proteins important in the determination of cell fate and maintenance of progenitors in many developmental systems. This family of proteins function both as membrane cell receptors and as transcription factors. Activation of Notch by cell-cell interactions causes a transcription inhibitory effect that enables inhibition of differentiation in some cells but not in others. As a consequence, some cells adopt a particular fate while other progenitors remain uncommitted. The Notch protein is important in cell fate during myogenesis, neurogenesis, oogenesis, and wing and eye development in Drosophila. In mammals, four Notch genes were identified (Notch 1-4) that are expressed in a wide variety of cells and play a crucial role in differentiation and development.
特异性
Notch1
免疫原
N-terminal GST fusion protein corresponding to residues 381-853 of rat Notch1
应用
Anti-Notch1 Antibody, extracellular domain is a high quality Rabbit Polyclonal Antibody for the detection of Notch1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Used in mouse in the following publication: Gulino, R., et al, European Journal of Neuroscience, Vol. 31, pp. 1423–1434, 2010.
质量
Routinely evaluated by immunoblot on RIPA lysates from L/N17 rat Notch1 transfected fibroblast cells
目标描述
260kDa
联系
Replaces: 04-1046
外形
Protein A chromatography
Format: Purified
Protein A purified immunoglobulin presented in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH 7.4
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
L/N17 transfected Notch1 cell lysate
L/N17 transfected Notch1 cell lysate
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10-13 - German Storage Class 10 to 13
NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
Oswald, F, et al
Molecular and cellular biology, 18, 2077-2088 (1998)
S Jarriault et al.
Molecular and cellular biology, 18(12), 7423-7431 (1998-11-20)
The Notch receptor is involved in many cell fate determination events in vertebrates and invertebrates. It has been shown in Drosophila melanogaster that Delta-dependent Notch signaling activates the transcription factor Suppressor of Hairless, leading to an increased expression of the
C M Blaumueller et al.
Cell, 90(2), 281-291 (1997-07-25)
Previous models for signal transduction via the Notch pathway have depicted the full-length Notch receptor expressed at the cell surface. We present evidence demonstrating that the Notch receptor on the plasma membrane is cleaved. This cleavage is an evolutionarily conserved
G Struhl et al.
Cell, 93(4), 649-660 (1998-05-30)
The Drosophila Notch (N) gene encodes a conserved single-pass transmembrane receptor that transduces extracellular signals controlling cell fate. Here, we present evidence that the intracellular domain of Notch gains access to the nucleus in response to ligand, possibly through a
Notch signaling: direct or what?
Weinmaster, G
Current Opinion in Genetics & Development, 8, 436-442 (1998)
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