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Merck
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文件

857133C

Avanti

18:1 BMP (S,R)

bis(monooleoylglycero)phosphate (S,R Isomer) (ammonium salt), chloroform

别名:

sn-(3--(9Z-octadecenoyl)-2-hydroxy)-glycerol-1-phospho-sn-3′-(1′--(9Z-octadecenoyl)-2′-hydroxy)-glycerol (ammonium salt); lysobisphosphatidic acid; LBPA; 110729

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About This Item

经验公式（希尔记法）:
C42H82NO10P
CAS号:
326495-20-9
分子量:
792.07
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (BMP (contains 30% positional isomers), TLC)

形狀

liquid

包裝

pkg of 1 × 1 mL (857133C-5mg)
pkg of 1 × 2 mL (857133C-50mg)

製造商／商標名

Avanti Research™ - A Croda Brand 857133C

濃度

25 mg/mL (857133C-50mg)
5 mg/mL (857133C-5mg)

脂質類型

cardiolipins
phospholipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@](COP(OC[C@@]([H])(O)COC(CCCCCCC/C=C\CCCCCCCC)=O)([O-])=O)(O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

相关类别

一般說明

Bis(monoacylglycerol)phosphate (BMP), an acidic phospholipid is mostly found in the lysosomal and endosomal compartments within cells.

應用

18:1 BMP (S,R) is suitable for the analysis of Niemann-Pick C2 (NPC2)-lipid interaction.

生化／生理作用

Bis(monoacylglycerol)phosphate (BMP) plays a vital role in late endosomes/lysosomes (LE/Lys) degradation pathway. It is involved in digestion and recycling of membranous materials and synthesis of intra luminal vesicles. BMP also regulates cholesterol homeostasis and trafficking of lysosomal enzymes.

包裝

5 mL Clear Glass Sealed Ampule (857133C-50mg)
5 mL Clear Glass Sealed Ampule (857133C-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

標靶器官

Liver,Kidney, Respiratory system

水污染物質分類（WGK）

WGK 3

分析证书(COA)

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Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
McCauliff LA, et al.
eLife, 8 (2019)
Ion mobility and tandem mass spectrometry of phosphatidylglycerol and bis (monoacylglycerol) phosphate (BMP)
Hankin JA, et al.
International Journal of Mass Spectrometry, 378, 255-263 (2015)
Nanjun Liu et al.
Toxicology and applied pharmacology, 279(3), 467-476 (2014-06-27)
The inability to routinely monitor drug-induced phospholipidosis (DIPL) presents a challenge in pharmaceutical drug development and in the clinic. Several nonclinical studies have shown di-docosahexaenoyl (22:6) bis(monoacylglycerol) phosphate (di-22:6-BMP) to be a reliable biomarker of tissue DIPL that can be
Elena Zaitseva et al.
PLoS pathogens, 6(10), e1001131-e1001131 (2010-10-16)
Many enveloped viruses invade cells via endocytosis and use different environmental factors as triggers for virus-endosome fusion that delivers viral genome into cytosol. Intriguingly, dengue virus (DEN), the most prevalent mosquito-borne virus that infects up to 100 million people each

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