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700133P

Avanti

3β,25-OH-7-oxo-5-cholestenoic acid

Avanti Research™ - A Croda Brand 700133P, powder

别名:

3β,25-dihydroxy-7-oxo-5-cholestenoic acid

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About This Item

经验公式（希尔记法）:
C27H42 O5
CAS号:
1036844-01-5
分子量:
446.62
分類程式碼代碼:
12352211
NACRES:
NA.25
价格与库存信息目前不能提供

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (700133P-1mg)

製造商／商標名

Avanti Research™ - A Croda Brand 700133P

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

O[C@H](C1)CC[C@](C1=C[C@H]2O)(C)C3C2C(CC[C@@H]4[C@H](C)CCCC(C)(O)CO)[C@]4(C)CC3

InChI 密鑰

JGEBMCVWDISKRI-MRAVHIDRSA-N

相关类别

一般說明

3β,25-OH-7-oxo-5-cholestenoic acid is a cholesterol derivative and an oxysterol derived from cholesterol. The synthesis of CA occurs in mitochondria and the enzyme sterol 27-hydroxylase (CYP27A1) catalyzes the step.[1]

生化／生理作用

Cholestenoic acid (CA) serves as a ligand to nuclear receptor and may be neurotoxic or neuroprotective based on their structural features.[2] Defects in the enzymes catalyzing the formation of cholestenoic acids are implicated in disorders related to motor neuron degeneration.[3]

包裝

5 mL Amber Glass Screw Cap Vial (700133P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Spyridon Theofilopoulos et al.
The Journal of clinical investigation, 124(11), 4829-4842 (2014-10-02)
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, we evaluated the cholestenoic acid profile of mammalian cerebrospinal fluid (CSF) and
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.
Jennifer H Madenspacher et al.
The Journal of allergy and clinical immunology, 143(1), 440-442 (2018-10-09)
Peter J Crick et al.
The Journal of steroid biochemistry and molecular biology, 195, 105475-105475 (2019-09-22)
While the presence and abundance of the major oxysterols and cholestenoic acids in the circulation is well established, minor cholesterol metabolites may also have biological importance and be of value to investigate. In this study by observing the metabolism of

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