NISCH
nischarin
别名:
I-1, IR1, IRAS, hIRAS
物种:
Human NISCH (11188), Mouse Nisch (64652), Rat Nisch (306255), Zebrafish nisch (553087), chicken NISCH (415893), domestic cat NISCH (101083249), dog NISCH (476594), sheep NISCH (101111584), domestic guinea pig Nisch (100730252), cow NISCH (515009) ...展开
UniProtKB ID:
基因ID:
- Human(11188) Summary: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
- Mouse(64652) nischarin
- Rat(306255) nischarin
- Zebrafish(553087) nischarin
- chicken(415893) nischarin
- domestic cat(101083249) nischarin
- dog(476594) nischarin
- sheep(101111584) nischarin
- domestic guinea pig(100730252) nischarin
- cow(515009) nischarin
- Horse(100060179) nischarin
- Domestic Rabbit(100346537) nischarin
- naked mole-rat(101701602) nischarin
- cow(100336473) nischarin
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Small Molecule - Agonist
Antibodies
货号
说明
物种反应性
应用
Anti-NISCH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-NISCH antibody produced in mouse, clone 2C8, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
Monoclonal Anti-NISCH antibody produced in mouse, clone 3B8, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot