跳转至内容
Merck

GALE

UDP-galactose-4-epimerase

别名:
SDR1E1
物种:
UniProtKB ID:
基因ID:
  • Human(2582) Summary: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(74246) galactose-4-epimerase, UDP
  • Rat(114860) UDP-galactose-4-epimerase
  • cow(523154) UDP-galactose-4-epimerase
  • sheep(101120144) UDP-galactose-4-epimerase
  • naked mole-rat(101714632) UDP-galactose-4-epimerase
  • domestic guinea pig(100722082) UDP-galactose-4-epimerase
  • Zebrafish(678540) UDP-galactose-4-epimerase
  • fruit fly(38076) UDP-galactose 4'-epimerase
  • chicken(419686) UDP-galactose-4-epimerase
  • domestic cat(101099312) UDP-galactose-4-epimerase
  • dog(487373) UDP-galactose-4-epimerase

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

货号
说明
物种反应性
应用
Anti-GALE antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-GALE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry

western blot
Anti-Gale Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human GALE,
物种
human
MISSION® esiRNA, targeting mouse Gale,
物种
mouse