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Merck

BRCC3

BRCA1/BRCA2-containing complex, subunit 3

别名:
BRCC36, C6.1A, CXorf53
物种:
UniProtKB ID:
基因ID:
  • Human(79184) Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
  • Mouse(210766) BRCA1/BRCA2-containing complex, subunit 3
  • Rat(316794) BRCA1/BRCA2-containing complex, subunit 3
  • sheep(101114756) BRCA1/BRCA2-containing complex, subunit 3
  • domestic cat(101096553) BRCA1/BRCA2-containing complex, subunit 3
  • domestic guinea pig(100719736) BRCA1/BRCA2-containing complex, subunit 3
  • dog(612642) BRCA1/BRCA2-containing complex, subunit 3
  • cow(519513) BRCA1/BRCA2-containing complex, subunit 3
  • chicken(422201) BRCA1/BRCA2-containing complex, subunit 3
  • naked mole-rat(101719523) BRCA1/BRCA2-containing complex, subunit 3
  • Horse(100062237) BRCA1/BRCA2-containing complex, subunit 3

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Antibodies

货号
说明
物种反应性
应用
Anti-BRCC3 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human
应用
immunofluorescence
western blot
Anti-BRCC3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
Anti-BRCC3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human BRCC3,
物种
human