ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
别名:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
物种:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
UniProtKB ID:
基因ID:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Thale Cress(818265) ABC transporter B family member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
货号
说明
物种
Small Molecule - Antagonist
Antibodies
货号
说明
物种反应性
应用
抗p-糖蛋白(MDR) 小鼠抗, clone F4, ascites fluid,
物种反应性
hamster, human
应用
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse
应用
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-Glycoprotein (MDR) antibody, Mouse monoclonal, clone F4, purified from hybridoma cell culture,
物种反应性
hamster, human
应用
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-ABCB1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep, zebrafish
应用
immunohistochemistry
western blot
western blot
Cell Lines
Kits
货号
说明
物种
Small Molecule - Mixed Agonist/Antagonist
货号
说明
物种
地塞米松, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
物种
mouse, rat, human
esiRNA
货号
说明
物种