Morken Group – Professor Product Portal
Professor James Morken
Chiral organoboronic esters are well known as versatile intermediates for chemical synthesis. Not only are these compounds stable under a variety of reaction conditions, they are generally non-toxic and can be transformed with minimal generation of hazardous waste. An important feature of aliphatic organoboronic esters is that the boron atom may be replaced with an array of different functional groups through efficient, stereospecific transformations. Our research focuses of the development of new strategies for the construction of alkyl boronic esters from simple starting materials in a catalytic enantioselective fashion.
Recent papers from the Morken Group
1.
Fang L, Yan L, Haeffner F, Morken JP. 2016. Carbohydrate-Catalyzed Enantioselective Alkene Diboration: Enhanced Reactivity of 1,2-Bonded Diboron Complexes. J. Am. Chem. Soc.. 138(8):2508-2511. https://doi.org/10.1021/jacs.5b13174
2.
Mlynarski SN, Schuster CH, Morken JP. 2014. Asymmetric synthesis from terminal alkenes by cascades of diboration and cross-coupling. Nature. 505(7483):386-390. https://doi.org/10.1038/nature12781
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DISCIPLINES
- Organic Synthetic Chemistry
- Catalysis
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