Alexanian Group - Professor Product Portal
Professor Erik Alexanian
The Alexanian group produces functionalized amides that enable a broad range of practical aliphatic C–H transformations. These reactions proceed in useful chemical yields with the substrate as limiting reagent under visible light or radical initiation. The C–H functionalizations occur with good levels of site selectivity, and a variety of common functionality is tolerated. The versatility of the functional groups introduced via these reactions unlocks a wide array of C–H transformations for organic synthesis.
Learn more in the recent publication in Science.
Recent papers from the Alexanian Group
1.
Fazekas TJ, Alty JW, Neidhart EK, Miller AS, Leibfarth FA, Alexanian EJ. 2022. Diversification of aliphatic C?H bonds in small molecules and polyolefins through radical chain transfer. Science. 375(6580):545-550. https://doi.org/10.1126/science.abh4308
2.
Czaplyski WL, Na CG, Alexanian EJ. 2016. C-H Xanthylation: A Synthetic Platform for Alkane Functionalization. J. Am. Chem. Soc.. 138(42):13854-13857. https://doi.org/10.1021/jacs.6b09414
3.
Quinn RK, Könst ZA, Michalak SE, Schmidt Y, Szklarski AR, Flores AR, Nam S, Horne DA, Vanderwal CD, Alexanian EJ. 2016. Site-Selective Aliphatic C?H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide. J. Am. Chem. Soc.. 138(2):696-702. https://doi.org/10.1021/jacs.5b12308
4.
Schmidt VA, Quinn RK, Brusoe AT, Alexanian EJ. 2014. Site-Selective Aliphatic C?H Bromination UsingN-Bromoamides and Visible Light. J. Am. Chem. Soc.. 136(41):14389-14392. https://doi.org/10.1021/ja508469u
DISCIPLINES
- Organic Synthetic Chemistry
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