- An improved radiosynthesis of O-(2-[
An improved radiosynthesis of O-(2-[
Journal of labelled compounds & radiopharmaceuticals (2017-04-14)
Kiel D Neumann, Charles M Thompson, Joseph E Blecha, John M Gerdes, Henry F VanBrocklin
PMID28406525
ABSTRACT
O-(2-Fluoroethyl)-O-(p-nitrophenyl) methylphosphonate 1 is an organophosphate cholinesterase inhibitor that creates a phosphonyl-serine covalent adduct at the enzyme active site blocking cholinesterase activity in vivo. The corresponding radiolabeled O-(2-[