Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

Product Number

Brand

Product Description

266647

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

266701

Sigma-Aldrich

Cobalt, wire, diam. 1.0 mm, 99.995% trace metals basis

356891

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

356867

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

357588

Sigma-Aldrich

Nickel, foil, thickness 0.1 mm, 99.98% trace metals basis

326380

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

357553

Sigma-Aldrich

Nickel, foil, thickness 0.5 mm, 99.98% trace metals basis

267074

Sigma-Aldrich

Nickel, rod, diam. 6.35 mm, ≥99.99% trace metals basis

357626

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.9% trace metals basis

266655

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

203076

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

266639

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

398810

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

697745

Sigma-Aldrich

Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

GF04944539

Cobalt, foil, light tested, 25x25mm, thickness 0.02mm, 99.9%

GF30616668

Cobalt, foil, not light tested, 25x25mm, thickness 0.002mm, temporary acrylic support, 99.9%

GF31581200

Cobalt, foil, not light tested, 50x50mm, thickness 0.009mm, 99.9%

GF41606131

Cobalt, microfoil, disks, 10mm, thinness 0.25μm, specific density 222μg/cm², permanent mylar 3.5μm support, 99.9%

GF95862134

Cobalt, microfoil, disks, 25mm, thinness 0.25μm, specific density 222μg/cm², permanent mylar 3.5μm support, 99.9%

GF83400364

Nickel, foil, not light tested, 100x100mm, thickness 0.002mm, 99.95%

GF42159315

Cobalt, foil, light tested, 25x25mm, thickness 0.009mm, 99.9%

GF25123159

Nickel, foil, 0.5m coil, thickness 0.0125mm, annealed, 99%

GF67355624

Nickel, foil, 0.5m coil, thickness 0.025mm, 99.9%

GF90435887

Nickel, foil, 0.5m coil, thickness 0.20mm, annealed, 99%

GF54065077

Nickel, foil, 10m coil, thickness 0.05mm, coil width 2mm, annealed, 99%

GF44673183

Nickel, foil, 0.5m coil, thickness 0.075mm, annealed, 99%

GF16803075

Nickel, foil, 2m coil, thickness 0.125mm, annealed, 99.98%

GF20895903

Nickel, microfoil, disks, 25mm, thinness 1.0μm, specific density 895.8μg/cm², permanent mylar 3.5μm support, 99.99+%

GF13212807

Nickel, pellets, 50g, max. size 5mm, 99.99+%

GF73011833

Nickel, foil, 50x50mm, thickness 1.0mm, annealed, 99.98%