- Total synthesis of 7',8'-dihydroaigialospirol.
Total synthesis of 7',8'-dihydroaigialospirol.
Organic letters (2012-09-29)
Tsz-Ying Yuen, Margaret A Brimble
PMID23016996
ABSTRACT
A highly convergent total synthesis of 7',8'-dihydroaigialospirol is described. Key steps of the synthesis include a Nozaki-Hiyama-Kishi (NHK) coupling of an iodoalkyne with an advanced phthalide-aldehyde and a remarkable one-pot acid-mediated global deprotection/spiroacetalization.
MATERIALS