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  • Preparation of (Cyanomethylene)tributylphosphorane: a new mitsunobu-type reagent.

Preparation of (Cyanomethylene)tributylphosphorane: a new mitsunobu-type reagent.

Chemical & pharmaceutical bulletin (2005-11-08)
Izumi Sakamoto, Takeshi Nishii, Fumie Ozaki, Hiroto Kaku, Masami Tanaka, Tetsuto Tsunoda
PMID16272744
ABSTRACT

(Cyanomethylene)tributylphosphorane (CMBP), which promoted the alkylation of various nucleophiles (HA) with alcohols (ROH) to give RA (Mitsunobu-type reaction), was prepared in two steps starting from chloroacetonitrile.