- Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives.
Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives.
European journal of medicinal chemistry (2002-01-05)
G Grynkiewicz, E Chojecka-Koryn, M Gadzikowska, A Chodkowska, E Jagiełło-Wójtowicz
PMID11755237
ABSTRACT
A group of 11 derivatives of chelidonine was obtained by acylations and/or alkylations of the secondary hydroxyl group with the aim of testing their biological activity. This paper focuses on the new derivatives influence on CNS in mice. The highest activity was observed for compounds 2c, 3c and 4, which produced antinociceptive and antiserotoninergic effects, not recorded for the parent alkaloid 1.
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