PZ0342

PF-6274484

≥98% (HPLC)

• Synonym(s): N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
• Empirical Formula (Hill Notation): C₁₈H₁₄ClFN₄O₂
• CAS Number: 1035638-91-5
• Molecular Weight: 372.78
• MDL number: MFCD30182370
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823851
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32
• InChI: 1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25)
• InChI key: DTMQCGFVWWBONL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC₅₀ values of 5.8 nM and 6.6 nM, respectively.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable