SPAM1
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Synonyms:
HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15
Species:
Human SPAM1 (6677), Mouse Spam1 (20690), Rat Spam1 (117037), naked mole-rat Spam1 (101700218), domestic guinea pig Spam1 (100135624), Domestic Rabbit SPAM1 (100009391), chicken SPAM1 (417749), cow SPAM1 (353352), domestic cat SPAM1 (101095731), dog SPAM1 (475211) ...More
UniProtKB ID:
Gene ID:
- Human(6677) Summary: Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
- Mouse(20690) sperm adhesion molecule 1
- Rat(117037) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
- naked mole-rat(101700218) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
- domestic guinea pig(100135624) sperm adhesion molecule 1
- Domestic Rabbit(100009391) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
- chicken(417749) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
- cow(353352) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
- domestic cat(101095731) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
- dog(475211) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
- Zebrafish(791203) sperm adhesion molecule 1
- Horse(100051243) sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SPAM1 (C-terminal) antibody produced in rabbit FITC conjugated, affinity isolated antibody,
Species Reactivity
human
Application
Anti-SPAM1 (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-SPAM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-SPAM1 (C-terminal) antibody produced in rabbit HRP conjugated, affinity isolated antibody,
Species Reactivity
human
Application
Anti-SPAM1 (C-terminal) antibody produced in rabbit biotin conjugated, affinity isolated antibody,
Species Reactivity
human
Application
esiRNA
Product Number
Description
Species