SH2D1A
SH2 domain containing 1A
Synonyms:
DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/SH2D1A, XLP, XLPD
Species:
Human SH2D1A (4068), Mouse Sh2d1a (20400), Rat Sh2d1a (501502), domestic guinea pig Sh2d1a (100722054), sheep SH2D1A (101117307), naked mole-rat Sh2d1a (101723893), cow SH2D1A (613356), domestic cat SH2D1A (101095723), dog SH2D1A (612899)
UniProtKB ID:
Gene ID:
- Human(4068) Summary: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(20400) SH2 domain protein 1A
- Rat(501502) SH2 domain containing 1A
- domestic guinea pig(100722054) SH2 domain containing 1A
- sheep(101117307) SH2 domain containing 1A
- naked mole-rat(101723893) SH2 domain containing 1A
- cow(613356) SH2 domain containing 1A
- domestic cat(101095723) SH2 domain containing 1A
- dog(612899) SH2 domain containing 1A
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SH2D1A antibody produced in mouse, clone 1C9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-SH2D1A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-SH2D1A antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Sh2D1A Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-SH2D1A/SLAM Associated Protein antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot