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  • The endocannabinoid system expression in the female reproductive tract is modulated by estrogen.

The endocannabinoid system expression in the female reproductive tract is modulated by estrogen.

The Journal of steroid biochemistry and molecular biology (2017-07-27)
J Maia, M Almada, A Silva, G Correia-da-Silva, N Teixeira, S I Sá, B M Fonseca
ABSTRACT

The endocannabinoid system (ECS) is involved in several physiological events that resulted in a growing interest in its modulation. Moreover, the uterine levels of anandamide (AEA), the major endocannabinoid, must be tightly regulated to create proper embryo implantation conditions. However, there are no evidences about the regulation of AEA in uterus by estrogen. Thus, the aim of this study is to elucidate whether estradiol benzoate (EB) and tamoxifen (TAM) administration to ovariectomized (OVX) rats can induce changes in the expression of cannabinoid receptors and AEA-metabolic enzymes in uterus by evaluating gene transcription and protein levels by qPCR, Western blot and immunohistochemistry. Moreover, the plasmatic and uterine levels of AEA and of prostaglandin E

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Ammonium acetate solution, BioUltra, for molecular biology, ~5 M in H2O
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Arachidonylethanolamide, ≥97.0% (TLC), oil
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SKUPack SizeAvailabilityPriceQuantity
25 g
Please contact Customer Service for Availability
69,80 CA$
100 g
Please contact Customer Service for Availability
165,00 CA$
250 g
Please contact Customer Service for Availability
345,00 CA$
1 kg
Please contact Customer Service for Availability
983,00 CA$
5 kg
Please contact Customer Service for Availability
3 590,00 CA$
25 kg
Please contact Customer Service for Availability
11 860,00 CA$
25 kg
Please contact Customer Service for Availability
12 290,00 CA$
50 kg
Please contact Customer Service for Availability
19 880,00 CA$