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Surface charge switching nanoparticles for magnetic resonance imaging.

Surface charge switching nanoparticles for magnetic resonance imaging.

International journal of pharmaceutics (2014-05-27)

Dong Jin Lee, Young Taik Oh, Eun Seong Lee

ABSTRACT

In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

MATERIALS

Product Number

Brand

Product Description

Lauric acid, European Pharmacopoeia (EP) Reference Standard

Supelco

Triethylamine, analytical standard

Sigma-Aldrich

N,N-Dimethylformamide, ACS reagent, ≥99.8%

Sigma-Aldrich

Acetic acid, glacial, ≥99.99% trace metals basis

Sigma-Aldrich

Diethyl ether, reagent grade, ≥98%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor

Sigma-Aldrich

Diethyl ether, ACS reagent, anhydrous, ≥99.0%, contains BHT as inhibitor

Sigma-Aldrich

Diethyl ether, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor

Sigma-Aldrich

N,N-Dimethylformamide, biotech. grade, ≥99.9%

Sigma-Aldrich

Acetic acid solution, suitable for HPLC

Sigma-Aldrich

N,N-Dimethylformamide, ReagentPlus^®, ≥99%

Sigma-Aldrich

Acetic acid, glacial, ReagentPlus^®, ≥99%

Sigma-Aldrich

Diethyl ether, ACS reagent, ≥98.0%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor

Sigma-Aldrich

Triethylamine, ≥99%

Sigma-Aldrich

Triethylamine, ≥99.5%

Sigma-Aldrich

N,N-Dimethylformamide, for molecular biology, ≥99%

Supelco

N,N-Dimethylformamide, analytical standard

Supelco

Diethyl ether, analytical standard

Sigma-Aldrich

Bis(trichloromethyl) carbonate, purum, ≥99.0% (AT)

Sigma-Aldrich

Acetic acid, for luminescence, BioUltra, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, for amino acid analysis, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, BioUltra, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, puriss. p.a., ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, for protein sequence analysis, ampule, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, ≥99.5%

Sigma-Aldrich

Acetic acid, ≥99.5%, FCC, FG

Sigma-Aldrich

Dodecylamine, 98%

Sigma-Aldrich

N,N-Dimethylformamide, anhydrous, 99.8%

Sigma-Aldrich

Lauric acid, natural, ≥98%, FCC, FG

Sigma-Aldrich

Diethyl ether

Sigma-Aldrich

Lauric acid, ≥98%, FCC, FG