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Merck

Facile oxidation of aldehydes to acids and esters with Oxone.

Organic letters (2003-03-28)
Benjamin R Travis, Meenakshi Sivakumar, G Olatunji Hollist, Babak Borhan
ABSTRACT

[reaction: see text] A highly efficient, mild, and simple protocol is presented for the oxidation of aldehydes to carboxylic acids utilizing Oxone as the sole oxidant. Direct conversion of aldehydes in alcoholic solvents to their corresponding ester products is also reported. These reactions may prove to be valuable alternatives to traditional metal-mediated oxidations.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
OXONE®, monopersulfate compound
Sigma-Aldrich
OXONE®, monopersulfate compound, free-flowing, Redi-Dri