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  • Versatile approaches for the synthesis of fused-ring γ-lactones utilizing cyclopropane intermediates.

Versatile approaches for the synthesis of fused-ring γ-lactones utilizing cyclopropane intermediates.

Organic letters (2013-03-09)
Timothy R Newhouse, Philip S J Kaib, Andrew W Gross, E J Corey
PMID23470216
ABSTRACT

A highly effective acid-catalyzed cyclopropyl ester to γ-lactone skeletal rearrangement has been demonstrated and applied to the synthesis of a variety of bi- and tricyclic functionalized lactones, rigid and highly compact structures for use as biological probes.