- Tetrodotoxin derivatives in puffer fish.
Tetrodotoxin derivatives in puffer fish.
Toxicon : official journal of the International Society on Toxinology (1985-01-01)
M Nakamura, T Yasumoto
PMID4024136
ABSTRACT
Analysis of puffer fish tissue extracts by a fluorometric tetrodotoxin analyzer revealed the presence of three tetrodotoxin derivatives besides tetrodotoxin. The derivatives were isolated and identified as tetrodonic acid, 4-epitetrodotoxin and anhydrotetrodotoxin on the basis of mass spectral and 1H NMR measurements. The lethal potencies of 4-epitetrodotoxin and anhydrotetrodotoxin to mice by i.p. injection were 710 and 92 mouse units/mg, respectively.