- Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.
Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.
ACS chemical biology (2017-10-05)
Seung H Choi, Madhupriya Mahankali, Sang Jun Lee, Mitchell Hull, H Michael Petrassi, Arnab K Chatterjee, Peter G Schultz, Katherine A Jones, Weijun Shen
PMID28976731
ABSTRACT
Myc plays important roles in cell cycle progression, cell growth, and stem cell self-renewal. Although dysregulation of Myc expression is a hallmark of human cancers, there is no Myc targeted therapy yet. Here, we report sAJM589, a novel small molecule Myc inhibitor, identified from a PCA-based high-throughput screen. sAJM589 potently disrupts the Myc-Max heterodimer in a dose dependent manner with an IC
MATERIALS