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Key Documents

SAB4300170

Sigma-Aldrich

Anti-phospho-TH (pSer40) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-TYH antibody produced in rabbit, Anti-tyrosine hydroxylase antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

55-60 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200

isotype

IgG

immunogen sequence

(R-Q-SP-L-I)

NCBI accession no.

NP_000351.2

UniProt accession no.

P07101

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer40)

Gene Information

human ... TH(7054)

Immunogen

Peptide sequence around phosphorylation site of serine 40 (R-Q-S(p)-L-I), according to the protein TH.

Features and Benefits

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Target description

The protein encoded by Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Kyoung In Kim et al.
Experimental neurobiology, 28(2), 289-299 (2019-05-30)
Transient receptor potential vanilloid subtype 1 (TRPV1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (DA) neurons in MPP+-lesioned rats via ciliary neurotrophic factor (CNTF). The present study determined whether such a beneficial effect of astrocytic TRPV1 could be achieved
Bárbara Rangel da Silva et al.
Cellular and molecular neurobiology, 39(1), 99-109 (2018-11-16)
Neurospheres prepared from multipotent progenitors in the retina obtained from postnatal mice differentiate into neurons and Müller glia (De Melo Reis et al., in Cell Mol Neurobiol 31:835-846, 2011). Here, we investigated whether neurospheres prepared from adult chickens (ciliary marginal
Rosilane Taveira-da-Silva et al.
Kidney & blood pressure research, 44(1), 1-11 (2019-02-28)
Dopamine (DA) is a natriuretic hormone that inhibits renal sodium reabsorption, being Angiotensin II (Ang II) its powerful counterpart. These two systems work together to maintain sodium homeostasis and consequently, the blood pressure (BP) within normal limits. We hypothesized that

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