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L6649

Sigma-Aldrich

Lonomycin A sodium salt from Streptomyces ribosidificus

90-95% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C44H75NaO14
CAS Number:
58845-80-0
Molecular Weight:
851.05
Beilstein:
4122659
MDL number:
MFCD00133488
UNSPSC Code:
12352200
PubChem Substance ID:
329817642

Assay

90-95% (TLC)

storage temp.

2-8°C

SMILES string

[Na+].CO[C@H]1C[C@]2(CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H]4O[C@H]([C@H](OC)[C@@H]4C)[C@H]5O[C@](C)(O)[C@H](C)[C@@H](OC)[C@@H]5C)O[C@@H]([C@@H]1C)[C@@H](C)[C@H]6O[C@](O)([C@H](C)[C@@H](OC)[C@H]6C)[C@H](C)C([O-])=O

InChI

1S/C44H76O14.Na/c1-21-29(49-12)20-43(56-31(21)22(2)32-23(3)34(51-14)27(7)44(48,57-32)28(8)39(45)46)19-18-40(9,58-43)30-16-17-41(10,54-30)38-25(5)35(52-15)37(53-38)36-24(4)33(50-13)26(6)42(11,47)55-36;/h21-38,47-48H,16-20H2,1-15H3,(H,45,46);/q;+1/p-1/t21-,22-,23+,24+,25+,26-,27-,28-,29+,30-,31+,32-,33+,34+,35-,36+,37-,38-,40+,41+,42+,43-,44-;/m1./s1

InChI key

PIKGYGHAIOUQMF-SZCYNZSUSA-M

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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D S Hoover et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 8(12), 1371-1380 (1998-01-07)
Expression of Pim-1, an oncogenic serine/threonine kinase, is highly regulated at the transcriptional, posttranscriptional, and posttranslational levels. Here, we report that expression of Pim-1 kinase is additionally regulated at the translational level. Pim-1 protein expression did not increase in Hut-78
A Saito et al.
Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology, 264(3-4), 446-454 (1987-05-01)
The inhibition of Toxoplasma multiplication inside cells does not correlate with an enhanced release of oxygen intermediates except in the case of peritoneal macrophages treated with Obioactin. The inhibition observed in alveolar macrophages treated with Obioactin, in kidney cells treated
B Marks et al.
Current biology : CB, 8(13), 740-749 (1998-07-04)
Following exocytosis at the synapse, synaptic vesicle components are recovered by endocytosis. Morphological analysis has suggested that this occurs by a clathrin-mediated pathway, and the GTPase dynamin is thought to be involved in 'pinching off' endocytosing vesicles. The finding that
[Application of nuclear magnetic resonance to bio-organic chemistry].
J Y Lallemand
Bulletin et memoires de l'Academie royale de medecine de Belgique, 137(8-9), 453-456 (1982-01-01)
K Kaneko et al.
Research communications in chemical pathology and pharmacology, 67(1), 17-30 (1990-01-01)
Lonomycin A, an ionophorous antibiotic, exhibits a high transport rate for monovalent cations, especially potassium. The cardiovascular actions of lonomycin A were studied in anesthetized dogs. Lonomycin A administered intravenously at 30 micrograms/kg increased coronary blood flow slightly with relatively
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