Journal of magnetic resonance (San Diego, Calif. : 1997), 189(1), 20-31 (2007-09-18)
The (1)H-(13)C solid-state NMR heteronuclear correlation (HETCOR) experiment is demonstrated to provide shift assignments in certain powders that have two or more structurally independent molecules in the unit cell (i.e. multiple molecules per asymmetric unit). Although this class of solids
Bioscience, biotechnology, and biochemistry, 76(12), 2360-2363 (2012-12-12)
(11S)-2α-Bromo-3-oxoeudesmano-12,6α-lactone, designated santonin-related compound 2 (SRC2), only weakly affected IκBα degradation after tumor necrosis factor-α (TNF-α) stimulation, but strongly blocked the nuclear translocation of nuclear factor κB (NF-κB) subunit p65. Replacement of Cys-38 of p65 with serine abolished the inhibitory
European journal of medicinal chemistry, 45(12), 6045-6051 (2010-10-26)
Ten novel α-santonin derivatives have been synthesized as cytotoxic agents. The in vitro antitumor activity of these compounds has been evaluated against cancer cells lines. Structure-activity relationships indicate that α-methylene-γ-lactone and endoperoxide functionalities play important roles in conferring cytotoxicity. The
Homeopathy : the journal of the Faculty of Homeopathy, 95(3), 144-147 (2006-07-04)
Lady's finger plants (Hibiscus esculentus), grown in pots, were inoculated with the second-stage larvae (76+/-6) of root-knot nematodes Meloidogyne incognita, starting 7 days later they were treated with Cina 30c, Santonin 30c or Ethanol 30c by foliar spray for 10
European journal of medicinal chemistry, 44(9), 3739-3745 (2009-05-02)
Ten alpha-santonin derivatives were synthesized in moderate to high yields. Four derivatives namely 10alpha-acetoxy-3-oxo-1,7alphaH,6,11betaH-guai-4-en-6,12-olide (2), isofotosantonic acid (3), 10alpha-hydroxy-3-oxo-1,7alphaH,6,11betaH-guai-4-en-6,12-olide (4), and lumisantonin (5), were prepared by different photochemical reactions using alpha-santonin (1) as starting material. These transformations were carried out
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