401490
IKK-2 Inhibitor XI
The IKK-2 Inhibitor XI, also referenced under CAS 354810-80-3, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Synonym(s):
IKK-2 Inhibitor XI, (5-Phenyl-3-ureido)-thiophene-2-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C12H11N3O2S
CAS Number:
Molecular Weight:
261.30
UNSPSC Code:
12352200
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable thiophenecarboxamide-ureido compound that acts as a potent, ATP-binding pocket-targeting inhibitor of IKK-2 (IC50 = 25 nM), while affecting IKK-1 and JNK1 only at much higher concentrations (IC50 = 1.0 and 1.6 µM, respectively). Shown to reduce LPS-induced TNF-α production in PBMCs (IC50 = 250 nM) and exhibit oral availability with good pharmacokinetic in rats in vivo.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Baxter, A., et al. 2004. Bioorg. Med. Chem. Lett.14, 2817.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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