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Merck

FLNA

filamin A, alpha

Synonyms:
ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD
Species:
UniProtKB ID:
Gene ID:
  • Human(2316) Summary: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
  • Mouse(192176) filamin, alpha
  • Rat(293860) filamin A, alpha
  • domestic guinea pig(100725162) filamin A, alpha
  • Zebrafish(562529) filamin A, alpha (actin binding protein 280)
  • chicken(395261) filamin A, alpha
  • naked mole-rat(101702004) filamin A, alpha
  • Zebrafish(100534866) filamin A, alpha
  • sheep(101120390) filamin A, alpha
  • dog(481084) filamin A, alpha
  • Domestic Rabbit(100328754) filamin A, alpha
  • cow(281165) filamin A, alpha
  • domestic cat(101082637) filamin A, alpha

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Filamin A Antibody, clone 3X8Y9, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
Anti-Filamin A Antibody, clone PM6/317 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
[KO Validated]Anti-CD44 antibody produced in mouse, [Knockout Validated]purified monoclonal antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-phospho-Filamin-A (Ser2152) Antibody, clone PS2, clone PS2, from mouse,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunofluorescence

western blot
Rabbit anti-Filamin A Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human FLNA,
Species
human