- Comparison of three different purification methods for the routine preparation of [11C] Metomidate.
Comparison of three different purification methods for the routine preparation of [11C] Metomidate.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2003-08-28)
Markus Mitterhauser, Wolfgang Wadsak, Oliver Langer, Joern Schmaljohann, Georg Zettinig, Robert Dudczak, Helmut Viernstein, Kurt Kletter
PMID12941500
ABSTRACT
PET with (R)-[O-methyl-11C] metomidate ([11C] MTO) is an attractive method for the characterisation of adrenal masses discriminating lesions of adrenal cortical origin from noncortical lesions. [11C] MTO was prepared by the reaction of [11C] methyliodide with the corresponding free acid. Three purification methods have been compared. The method of choice uses preparative HPLC with a ready-to-use weak acidic solvent.
MATERIALS
Product Number
Brand
Product Description
Etomidate impurity B, European Pharmacopoeia (EP) Reference Standard