Aryl-heteroaryl derivatives as novel wake-promoting agents.

Aryl-heteroaryl derivatives as novel wake-promoting agents.

Chemical biology & drug design (2012-11-01)

Brigitte Lesur, Yin G Lin, Val R Marcy, Lisa D Aimone, John Gruner, Edward R Bacon, Sankar Chatterjee

ABSTRACT

In search of a next generation molecule to the novel wake-promoting agent modafinil, a series of aryl-heteroayl-derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile them individually.

MATERIALS

Product Number

Brand

Product Description

M-084

Supelco

Modafinil solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

M6940

Sigma-Aldrich

Modafinil, ≥98% (HPLC)

Y0000635

Modafinil, European Pharmacopoeia (EP) Reference Standard

Y0000636

Modafinil for system suitability, European Pharmacopoeia (EP) Reference Standard