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  • Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Journal of medicinal chemistry (2009-10-13)
Emeline L Maillet, Robert F Margolskee, Bedrich Mosinger
ABSTRACT

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Thus, certain effects of fibrates in treating hyperlipidemia and type II diabetes may be via actions on T1R3. Likewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetected in studies on rodents.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Indole-3-propionic acid, ≥97.0% (T)
Supelco
2,4-D, PESTANAL®, analytical standard
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1-Naphthaleneacetic acid, technical grade
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1-Naphthaleneacetic acid, PESTANAL®, analytical standard
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4-Chlorophenoxyacetic acid, PESTANAL®, analytical standard
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3-Indoleacetic acid, 98%
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3-Indoleacetic acid, suitable for plant cell culture, crystalline
Sigma-Aldrich
(±)-2-(p-Methoxyphenoxy)propionic acid, ≥98%
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1-Naphthaleneacetic acid, suitable for plant cell culture, BioReagent, ≥95%, crystalline
Sigma-Aldrich
4-Chlorophenoxyacetic acid, BioReagent, suitable for plant cell culture, crystalline
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Indole-3-propionic acid, ≥99.0% (T)
Sigma-Aldrich
4-Chlorophenoxyacetic acid, ≥98.0% (T)
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Dichloroprop-P, PESTANAL®, analytical standard
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3-Indoleacetic acid, PESTANAL®, analytical standard
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2,3,5-Trichlorobenzoic acid, 97%
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2,4-Dichlorophenoxyacetic acid, 97%
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2-(2,4,5-Trichlorophenoxy)propionic acid, PESTANAL®, analytical standard
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Indole-3-butyric acid, BioReagent, suitable for plant cell culture
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Dicamba, suitable for plant cell culture, BioReagent
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2,4-Dichlorophenoxyacetic acid, ≥95%, crystalline
Supelco
Dichlorprop, PESTANAL®, analytical standard
Sigma-Aldrich
Phenylacetic acid, ≥99%, FCC, FG
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Dicamba, PESTANAL®, analytical standard